GGA1

GGA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J2J, 1JWF, 1JWG, 1NA8, 1NAF, 1NWM, 1O3X, 1OM9, 1OXZ, 1PY1, 1UJJ, 1UJK, 1X79, 2DWX, 2DWY, 3G2S, 3G2T, 3G2U, 3G2V, 3G2W
Identifiers
Aliases	GGA1, golgi associated, gamma adaptin ear containing, ARF binding protein 1
External IDs	OMIM: 606004; MGI: 2146207; HomoloGene: 39250; GeneCards: GGA1; OMA:GGA1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	37,633,564 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,778,785 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; left testis; ; right testis; ; endothelial cell; ; right uterine tube; ; mucosa of ileum; ; right hemisphere of cerebellum; ; pituitary gland; ; gingival epithelium; ; anterior pituitary;
	Top expressed in
	granulocyte; ; muscle of thigh; ; lip; ; pyloric antrum; ; yolk sac; ; superior frontal gyrus; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; esophagus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein heterodimerization activity; molecular function;
Cellular component	endosome; Golgi apparatus; endosome membrane; intracellular anatomical structure; membrane; intracellular membrane-bounded organelle; clathrin adaptor complex; nucleoplasm; early endosome membrane; early endosome; cytosol; protein-containing complex;
Biological process	protein transport; intracellular protein transport; toxin transport; positive regulation of protein catabolic process; vesicle-mediated transport; transport; Golgi to plasma membrane transport; protein localization; protein localization to cell surface; retrograde transport, endosome to Golgi; Golgi to plasma membrane protein transport; protein localization to ciliary membrane;
	Sources:Amigo / QuickGO
Orthologs
	26088
	106039
	ENSG00000100083
	ENSMUSG00000033128
	Q9UJY5
	Q8R0H9
NM_001001560; NM_001001561; NM_001172687; NM_001172688; NM_013365;
	NM_001363771
	NM_145929
	NP_001001560; NP_001166158; NP_001166159; NP_037497; NP_001350700
	NP_666041
	Wikidata
View/Edit Human	View/Edit Mouse

ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene.

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.