GGA3

GGA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JPL, 1JUQ, 1LF8, 1P4U, 1WR6, 1YD8
Identifiers
Aliases	GGA3, golgi associated, gamma adaptin ear containing, ARF binding protein 3
External IDs	OMIM: 606006; MGI: 2384159; HomoloGene: 121703; GeneCards: GGA3; OMA:GGA3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	75,262,363 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	115,494,877 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; granulocyte; ; pylorus; ; gastric mucosa; ; spleen; ; monocyte; ; nipple; ; lymph node; ; upper lobe of left lung; ; fundus;
	Top expressed in
	zygote; ; secondary oocyte; ; neural layer of retina; ; tail of embryo; ; primary visual cortex; ; superior frontal gyrus; ; cerebellar cortex; ; yolk sac; ; facial motor nucleus; ; genital tubercle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin binding;
Cellular component	endosome; trans-Golgi network; endosome membrane; intracellular anatomical structure; membrane; clathrin adaptor complex; Golgi apparatus; early endosome membrane; recycling endosome membrane; early endosome; recycling endosome;
Biological process	protein transport; intracellular protein transport; positive regulation of protein catabolic process; vesicle-mediated transport; protein localization to lysosome; regulation of protein stability; protein destabilization; endocytic recycling; protein localization to cell surface; Golgi to plasma membrane protein transport; negative regulation of amyloid-beta formation;
	Sources:Amigo / QuickGO
Orthologs
	23163
	260302
	ENSG00000125447
	ENSMUSG00000020740
	Q9NZ52
	Q8BMI3
NM_001172703; NM_001172704; NM_001291641; NM_001291642; NM_014001;
	NM_138619
	NM_001252067; NM_173048
NP_001166174; NP_001166175; NP_001278570; NP_001278571; NP_054720;
	NP_619525
	NP_001238996; NP_766636
	Wikidata
View/Edit Human	View/Edit Mouse

ADP-ribosylation factor-binding protein GGA3 is a protein that in humans is encoded by the GGA3 gene.

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Alternative splicing of this gene results in two transcript variants.