Gamma-glutamyltransferase 5

GGT5
Identifiers
Aliases	GGT5, GGT-REL, GGTLA1, GGL, GGT 5, gamma-glutamyltransferase 5
External IDs	OMIM: 137168; MGI: 1346063; HomoloGene: 55802; GeneCards: GGT5; OMA:GGT5 - orthologs
EC number	3.4.19.14
Gene location (Human)
Chr.	Chromosome 22 (human)
End	24,245,108 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	75,453,034 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; right coronary artery; ; left lobe of thyroid gland; ; left coronary artery; ; left uterine tube; ; canal of the cervix; ; right auricle of heart; ; gastric mucosa; ; tibial nerve; ; subcutaneous adipose tissue;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; gastrula; ; uterus; ; cervix; ; muscle of thigh; ; mammary gland; ; lactiferous gland; ; decidua; ; mesenteric lymph nodes;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; peptidase activity; acyltransferase activity; hydrolase activity; leukotriene-C(4) hydrolase; glutathione hydrolase activity; hypoglycin A gamma-glutamyl transpeptidase activity; peptidyltransferase activity; leukotriene C4 gamma-glutamyl transferase activity;
Cellular component	plasma membrane; membrane; integral component of membrane; intrinsic component of plasma membrane;
Biological process	leukotriene metabolic process; glutathione biosynthetic process; inflammatory response; proteolysis; cellular amino acid metabolic process; glutathione metabolic process; glutathione catabolic process; leukotriene biosynthetic process; leukotriene D4 biosynthetic process; fatty acid metabolic process; protein biosynthesis; glutamate metabolic process; cysteine biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	2687
	23887
	ENSG00000099998
	ENSMUSG00000006344
	P36269
	Q9Z2A9
	NM_001099781; NM_001099782; NM_001302464; NM_001302465; NM_004121
	NM_011820; NM_001359425
	NP_001093251; NP_001093252; NP_001289393; NP_001289394; NP_004112
	NP_035950; NP_001346354
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-glutamyltransferase 5 is an enzyme that in humans is encoded by the GGT5 gene.

Gamma-glutamyltransferase-like activity 1 (GGTLA1) is a member of a gene family with at least 4 members (GGTLA1, GGTLA2, GGTLA3 and GGTLA4). The enzyme encoded by GGTLA1 is related to, but distinct from, gamma-glutamyl transpeptidase (GGT). The GGTLA1 enzyme consists of a heavy and a light chain and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert synthetic substrates that are commonly used to assay GGT. Its amino acid sequence shows an overall similarity of 39.5% with human GGT.