GHITM

GHITM
Identifiers
Aliases	GHITM, DERP2, HSPC282, MICS1, PTD010, TMBIM5, My021, growth hormone inducible transmembrane protein
External IDs	MGI: 1913342; HomoloGene: 8667; GeneCards: GHITM; OMA:GHITM - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	84,154,841 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	36,857,229 bp
RNA expression pattern
	Top expressed in
	sperm; ; right ventricle; ; myocardium of left ventricle; ; mucosa of ileum; ; deltoid muscle; ; tibialis anterior muscle; ; mucosa of colon; ; lateral nuclear group of thalamus; ; mucosa of sigmoid colon; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	blood; ; right kidney; ; cerebellar cortex; ; medial vestibular nucleus; ; brown adipose tissue; ; muscle of thigh; ; pontine nuclei; ; neural layer of retina; ; superior frontal gyrus; ; deep cerebellar nuclei;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; molecular function;
Cellular component	extracellular exosome; membrane; integral component of membrane; mitochondrial inner membrane; mitochondrion;
Biological process	apoptotic process; biological process;
	Sources:Amigo / QuickGO
Orthologs
	27069
	66092
	ENSG00000165678
	ENSMUSG00000041028
	Q9H3K2
	Q91VC9
	NM_014394
	NM_001199122; NM_078478; NM_001359902
	NP_055209
	NP_001186051; NP_510963; NP_001346831
	Wikidata
View/Edit Human	View/Edit Mouse

Growth hormone-inducible transmembrane protein (GHITM), also known as transmembrane BAX inhibitor motif containing protein 5 (TMBIM5), is a protein that in humans is encoded by the GHITM gene on chromosome 10. It is a member of the BAX inhibitor motif containing (TMBIM) family and localizes to the inner mitochondrial membrane (IMM), as well as the endoplasmic reticulum (ER), where it plays a role in apoptosis through mediating mitochondrial morphology and cytochrome c release. Through its apoptotic function, GHITM may be involved in tumor metastasis and innate antiviral responses.