GLA (gene)

GLA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1R46, 1R47, 3GXN, 3GXP, 3GXT, 3HG2, 3HG3, 3HG4, 3HG5, 3LX9, 3LXA, 3LXB, 3LXC, 3S5Y, 3S5Z, 3TV8, 4NXS
Identifiers
Aliases	GLA, GALA, galactosidase alpha
External IDs	OMIM: 300644; MGI: 1347344; HomoloGene: 90852; GeneCards: GLA; OMA:GLA - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	101,408,012 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	133,501,874 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; monocyte; ; seminal vesicula; ; amniotic fluid; ; stromal cell of endometrium; ; islet of Langerhans; ; bone marrow; ; blood; ; granulocyte; ; mucosa of transverse colon;
	Top expressed in
	decidua; ; granulocyte; ; stroma of bone marrow; ; morula; ; lumbar spinal ganglion; ; endothelial cell of lymphatic vessel; ; calvaria; ; blastocyst; ; ileum; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity, hydrolyzing O-glycosyl compounds; protein homodimerization activity; hydrolase activity, acting on glycosyl bonds; raffinose alpha-galactosidase activity; protein binding; galactoside binding; catalytic activity; signaling receptor binding; hydrolase activity; alpha-galactosidase activity;
Cellular component	cytoplasm; Golgi apparatus; lysosomal lumen; lysosome; extracellular exosome; extracellular region; azurophil granule lumen;
Biological process	negative regulation of nitric-oxide synthase activity; glycosphingolipid metabolic process; glycosphingolipid catabolic process; negative regulation of nitric oxide biosynthetic process; metabolism; oligosaccharide metabolic process; neutrophil degranulation; glycoside catabolic process; glycosylceramide catabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2717
	11605
	ENSG00000102393
	ENSMUSG00000031266
	P06280
	P51569
	NM_000169
	NM_013463
	NP_000160
	NP_038491
	Wikidata
View/Edit Human	View/Edit Mouse

Galactosidase alpha is an enzyme that in humans is encoded by the GLA gene.

Two recombinant forms of human α-galactosidase are called agalsidase alpha (INN) and agalsidase beta (INN). A mold-derived form is the primary ingredient in gas relief supplements.