Glycine dehydrogenase (decarboxylating)

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glycine decarboxylase
glycine decarboxylase
Identifiers
EC no.	1.4.4.2
CAS no.	37259-67-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

GLDC
Identifiers
Aliases	GLDC, GCE, GCSP, HYGN1, Glycine dehydrogenase, glycine decarboxylase
External IDs	OMIM: 238300; MGI: 1341155; HomoloGene: 141; GeneCards: GLDC; OMA:GLDC - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	6,645,729 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	30,152,829 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney tubule; ; gonad; ; human kidney; ; ventricular zone; ; sural nerve; ; placenta; ; metanephric glomerulus; ; testicle; ; embryo;
	Top expressed in
	otic placode; ; otic vesicle; ; yolk sac; ; morula; ; primitive streak; ; morula; ; epiblast; ; left lobe of liver; ; right kidney; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	lyase activity; electron transfer activity; oxidoreductase activity; catalytic activity; pyridoxal phosphate binding; protein dimerization activity; glycine binding; glycine dehydrogenase (decarboxylating) activity; protein homodimerization activity; pyridoxal binding; enzyme binding;
Cellular component	mitochondrial matrix; plasma membrane; nucleus; glycine cleavage complex; mitochondrion;
Biological process	cellular amino acid metabolic process; glycine metabolic process; glycine decarboxylation via glycine cleavage system; glycine catabolic process; response to methylamine; response to lipoic acid; cellular response to leukemia inhibitory factor; electron transport chain;
	Sources:Amigo / QuickGO
Orthologs
	2731
	104174
	ENSG00000178445
	ENSMUSG00000024827
	P23378
	Q91W43
	NM_000170
	NM_138595
	NP_000161
	NP_613061
	Wikidata
View/Edit Human	View/Edit Mouse

Glycine decarboxylase also known as glycine cleavage system P protein or glycine dehydrogenase is an enzyme that in humans is encoded by the GLDC gene.