GLI1

GLI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GLI, 4BLB, 4KMD
Identifiers
Aliases	GLI1, GLI, GLI family zinc finger 1, PAPA8, PPD1
External IDs	OMIM: 165220; MGI: 95727; HomoloGene: 3859; GeneCards: GLI1; OMA:GLI1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,472,268 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,177,843 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; sural nerve; ; gastric mucosa; ; canal of the cervix; ; testicle; ; dorsal motor nucleus of vagus nerve; ; rectum; ; blood; ; gonad; ; stromal cell of endometrium;
	Top expressed in
	spermatogonium; ; tooth; ; molar; ; Gonadal ridge; ; lip; ; genital tubercle; ; dermis; ; palate; ; epithelium of seminiferous tubule of testis; ; lower jaw;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; microtubule binding; chromatin binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; nucleic acid binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; cytosol; cilium; nucleoplasm; ciliary base; ciliary tip; axoneme; nucleus;
Biological process	epidermal cell differentiation; proximal/distal pattern formation; cell differentiation; pituitary gland development; regulation of transcription, DNA-templated; positive regulation of smoothened signaling pathway; lung development; positive regulation of cell migration; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation; notochord regression; transcription, DNA-templated; positive regulation of transcription, DNA-templated; positive regulation of DNA replication; ventral midline development; multicellular organism development; regulation of smoothened signaling pathway; liver regeneration; response to wounding; regulation of osteoblast differentiation; osteoblast differentiation; spermatogenesis; positive regulation of cell population proliferation; cerebellar cortex morphogenesis; regulation of hepatocyte proliferation; canonical Wnt signaling pathway; smoothened signaling pathway; dorsal/ventral pattern formation; negative regulation of canonical Wnt signaling pathway; positive regulation of transcription by RNA polymerase II; digestive tract morphogenesis; prostate gland development; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle G1/S phase transition;
	Sources:Amigo / QuickGO
Orthologs
	2735
	14632
	ENSG00000111087
	ENSMUSG00000025407
	P08151
	P47806
	NM_001160045; NM_001167609; NM_005269
	NM_010296
	NP_001153517; NP_001161081; NP_005260
	NP_034426
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated from human glioblastoma cells.