GLI3

GLI3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BLD
Identifiers
Aliases	GLI3, ACLS, GCPS, GLI3-190, GLI3FL, PAP-A, PAPA, PAPA1, PAPB, PHS, PPDIV, GLI family zinc finger 3
External IDs	OMIM: 165240; MGI: 95729; HomoloGene: 139; GeneCards: GLI3; OMA:GLI3 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	42,264,100 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	15,904,611 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; olfactory bulb; ; tendon of biceps brachii; ; tibia; ; ganglionic eminence; ; parietal pleura; ; nipple; ; triceps brachii muscle; ; glutes; ; buccal mucosa cell;
	Top expressed in
	maxillary prominence; ; genital tubercle; ; spermatogonium; ; mandibular prominence; ; tail of embryo; ; ureter; ; ventricular zone; ; abdominal wall; ; primitive streak; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; beta-catenin binding; chromatin binding; protein binding; histone acetyltransferase binding; nucleic acid binding; DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; mediator complex binding;
Cellular component	cytoplasm; cytosol; transcription repressor complex; nucleus; nuclear speck; cell projection; mediator complex; cilium; axoneme; nucleoplasm; ciliary base; ciliary tip;
Biological process	embryonic skeletal system morphogenesis; pattern specification process; lateral semicircular canal development; negative regulation of neuron differentiation; T cell differentiation in thymus; tongue development; nose morphogenesis; optic nerve morphogenesis; smoothened signaling pathway involved in ventral spinal cord interneuron specification; anatomical structure formation involved in morphogenesis; oligodendrocyte differentiation; hindgut morphogenesis; spinal cord dorsal/ventral patterning; thymocyte apoptotic process; mammary gland development; limb development; odontogenesis of dentin-containing tooth; positive regulation of chondrocyte differentiation; embryonic digestive tract morphogenesis; inner ear development; metanephros development; melanocyte differentiation; negative regulation of canonical Wnt signaling pathway; negative regulation of cell population proliferation; regulation of apoptotic process; positive regulation of neuroblast proliferation; regulation of transcription, DNA-templated; limb morphogenesis; negative regulation of smoothened signaling pathway; kidney development; lung development; tube development; embryonic organ development; lateral ganglionic eminence cell proliferation; negative regulation of cell differentiation; embryonic digit morphogenesis; negative regulation of alpha-beta T cell differentiation; in utero embryonic development; transcription, DNA-templated; negative thymic T cell selection; positive regulation of transcription, DNA-templated; heart development; central nervous system development; telencephalon development; branching involved in ureteric bud morphogenesis; embryonic limb morphogenesis; neural tube development; positive regulation of protein import into nucleus; smoothened signaling pathway; camera-type eye development; spinal cord motor neuron differentiation; positive regulation of alpha-beta T cell differentiation; lambdoid suture morphogenesis; regulation of bone development; roof of mouth development; proximal/distal pattern formation; anatomical structure development; wound healing; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; response to estrogen; cerebral cortex radial glia-guided migration; positive regulation of osteoblast differentiation; developmental growth; pallium development; mammary gland specification; frontal suture morphogenesis; anterior semicircular canal development; regulation of gene expression; negative regulation of transcription, DNA-templated; dorsal/ventral pattern formation; branching morphogenesis of an epithelial tube; embryonic digestive tract development; subpallium development; sagittal suture morphogenesis; forebrain dorsal/ventral pattern formation; protein processing; axon guidance; brain development; smoothened signaling pathway involved in dorsal/ventral neural tube patterning; forebrain radial glial cell differentiation; regulation of cell population proliferation; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; layer formation in cerebral cortex; embryonic morphogenesis; artery development; cell differentiation involved in kidney development; regulation of cell differentiation; forebrain development; neuron fate commitment; hippocampus development; camera-type eye morphogenesis; anterior/posterior pattern specification; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; prostate gland development; liver regeneration;
	Sources:Amigo / QuickGO
Orthologs
	2737
	14634
	ENSG00000106571
	ENSMUSG00000021318
	P10071
	Q61602
	NM_000168
	NM_008130
	NP_000159
	NP_032156
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein GLI3 is a protein that in humans is encoded by the GLI3 gene.

This gene encodes a protein that belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH1) gene expression. It is also thought to play a role during embryogenesis.