GLRB

GLRB
Identifiers
Aliases	GLRB, HKPX2, glycine receptor beta
External IDs	OMIM: 138492; MGI: 95751; HomoloGene: 20224; GeneCards: GLRB; OMA:GLRB - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	157,172,090 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	80,820,967 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; Brodmann area 10; ; middle frontal gyrus; ; lateral nuclear group of thalamus; ; Pons; ; paraflocculus of cerebellum; ; Brodmann area 23; ; dorsolateral prefrontal cortex; ; endothelial cell; ; primary visual cortex;
	Top expressed in
	lateral geniculate nucleus; ; mammillary body; ; pontine nuclei; ; medial vestibular nucleus; ; deep cerebellar nuclei; ; lobe of cerebellum; ; lateral hypothalamus; ; dorsal tegmental nucleus; ; cerebellar vermis; ; lateral septal nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	glycine binding; protein binding; extracellularly glycine-gated ion channel activity; chloride channel activity; extracellular ligand-gated ion channel activity; extracellularly glycine-gated chloride channel activity; ion channel activity; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	cytoplasm; integral component of membrane; postsynaptic membrane; cell projection; membrane; synapse; chloride channel complex; glycine-gated chloride channel complex; cell junction; dendrite; integral component of plasma membrane; plasma membrane; GABA-ergic synapse; glycinergic synapse; neuron projection;
Biological process	response to amino acid; startle response; protein heterooligomerization; regulation of membrane potential; gamma-aminobutyric acid receptor clustering; chloride transmembrane transport; nervous system development; acrosome reaction; neuromuscular process; righting reflex; chloride transport; neuropeptide signaling pathway; visual perception; adult walking behavior; ion transport; synaptic transmission, glycinergic; excitatory postsynaptic potential; chemical synaptic transmission; ion transmembrane transport; signal transduction; nervous system process; regulation of postsynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	2743
	14658
	ENSG00000109738
	ENSMUSG00000028020
	P48167
	P48168
	NM_000824; NM_001166060; NM_001166061
NM_001281969; NM_010298; NM_001345955; NM_001345956; NM_001345957;
	NM_001345958; NM_001345959; NM_001345996
	NP_000815; NP_001159532; NP_001159533
NP_001268898; NP_001332884; NP_001332885; NP_001332886; NP_001332887;
	NP_001332888; NP_001332925; NP_034428
	Wikidata
View/Edit Human	View/Edit Mouse

Glycine receptor subunit beta is a protein that in humans is encoded by the GLRB gene.

The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM 138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM]