GNG3

GNG3
Identifiers
Aliases	GNG3, G protein subunit gamma 3, HG3D
External IDs	OMIM: 608941; MGI: 102704; HomoloGene: 22575; GeneCards: GNG3; OMA:GNG3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	62,709,201 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	8,816,558 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; right hemisphere of cerebellum; ; dorsolateral prefrontal cortex; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 9; ; spinal ganglia; ; Amygdala; ; ganglionic eminence;
	Top expressed in
	perirhinal cortex; ; entorhinal cortex; ; central gray substance of midbrain; ; medial dorsal nucleus; ; CA3 field; ; inferior colliculi; ; subiculum; ; superior colliculus; ; primary motor cortex; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor binding; signal transducer activity; type 1 angiotensin receptor binding; protein binding; GTPase activity; G-protein beta-subunit binding;
Cellular component	cell body; plasma membrane; dendrite; membrane; heterotrimeric G-protein complex; postsynaptic density; G-protein beta/gamma-subunit complex;
Biological process	positive regulation of cytosolic calcium ion concentration; G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	2785
	14704
	ENSG00000162188
	ENSMUSG00000071658
	P63215
	P63216
	NM_012202
	NM_010316
	NP_036334
	NP_034446
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 is a protein that in humans is encoded by the GNG3 gene.

G proteins are heterotrimers of alpha, beta, and gamma subunits. Gamma subunits, such as GNG3, contribute to the specificity of the hundreds of receptor signaling pathways involving G proteins (Schwindinger et al., 2004).[supplied by OMIM]