GNL3

GNL3
Identifiers
Aliases	GNL3, C77032, E2IG3, NNP47, NS, G protein nucleolar 3
External IDs	OMIM: 608011; MGI: 1353651; HomoloGene: 56670; GeneCards: GNL3; OMA:GNL3 - orthologs
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	30,741,109 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; body of pancreas; ; islet of Langerhans; ; minor salivary glands; ; rectum; ; thymus; ; peritoneum; ; skin of abdomen; ; anterior pituitary; ; left uterine tube;
	Top expressed in
	tail of embryo; ; epiblast; ; genital tubercle; ; embryo; ; morula; ; embryo; ; ovary; ; uterus; ; blastocyst; ; placenta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; RNA binding; GTPase activity; mRNA 5'-UTR binding;
Cellular component	membrane; nucleus; nucleoplasm; nucleolus; extracellular space; nuclear body;
Biological process	positive regulation of protein localization to chromosome, telomeric region; positive regulation of telomere maintenance; cell population proliferation; regulation of cell population proliferation; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of protein sumoylation; stem cell division; stem cell population maintenance; ribosome biogenesis;
	Sources:Amigo / QuickGO
Orthologs
	26354
	30877
	n/a
	ENSMUSG00000042354
	Q9BVP2
	Q8CI11
	NM_206826; NM_014366; NM_206825
	NM_153547; NM_178846
	NP_055181; NP_996561; NP_996562
	NP_705775
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene. It is found within the nucleolus that binds p53. Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses. It is a marker for many stem cells and cancer cells.