GOLT1B

GOLT1B
Identifiers
Aliases	GOLT1B, GCT2, GOT1, GOT1B, YMR292W, CGI-141, golgi transport 1B
External IDs	OMIM: 615078; MGI: 1914214; HomoloGene: 41102; GeneCards: GOLT1B; OMA:GOLT1B - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	21,518,408 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	142,349,584 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; tibia; ; islet of Langerhans; ; endothelial cell; ; palpebral conjunctiva; ; pars reticulata; ; external globus pallidus; ; cartilage tissue; ; pars compacta; ; synovial joint;
	Top expressed in
	genital tubercle; ; ascending aorta; ; aortic valve; ; tail of embryo; ; embryo; ; otic placode; ; embryo; ; saccule; ; neural tube; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; endoplasmic reticulum; membrane;
Biological process	protein transport; positive regulation of I-kappaB kinase/NF-kappaB signaling; vesicle-mediated transport; signal transduction; transport;
	Sources:Amigo / QuickGO
Orthologs
	51026
	66964
	ENSG00000111711
	ENSMUSG00000030245
	Q9Y3E0
	Q9CR60
	NM_016072
	NM_025872
	NP_057156
	NP_080148
	Wikidata
View/Edit Human	View/Edit Mouse

Vesicle transport protein GOT1B is a protein that in humans is encoded by the GOLT1B gene.

Got1p is a protein that aides in vesicle transport through the Golgi apparatus of the cell. Got1p has a calculated mass of 15.4 kDa and consists of 138 residues. It is believed that the protein is a tetra-spanning membrane protein, and is evolutionarily conserved. Homologes of the protein have been found in Caenorhabditis elegans, Plasmodium falciparum, and in mammals. GOT1 is normally associated closely with Sf2p (encoded by sft2), which is another protein of similar function. In vivo, It has been found that the removal of these two proteins results in defects in endosome-Golgi traffic and ER-Golgi traffic. In vitro, the removal of got1 specifically, results in a defect in ER-Golgi transport in relation to vesicle tethering to Golgi membranes. The exact contribution that the protein has towards vesicle tethering is still a mystery, however, it is suspected that Got1p is involved in the release of Ca²⁺ in the Golgi membranes, causing ion channels associated with vesicle tethering to be affected.