Golgi reassembly-stacking protein 2

GORASP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3RLE, 4EDJ
Identifiers
Aliases	GORASP2, GOLPH6, GRASP55, GRS2, p59, golgi reassembly stacking protein 2
External IDs	OMIM: 608693; MGI: 2135962; HomoloGene: 9180; GeneCards: GORASP2; OMA:GORASP2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	170,967,130 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	70,542,980 bp
RNA expression pattern
	Top expressed in
	sperm; ; secondary oocyte; ; endothelial cell; ; tibia; ; parotid gland; ; islet of Langerhans; ; stromal cell of endometrium; ; cartilage tissue; ; corpus epididymis; ; palpebral conjunctiva;
	Top expressed in
	Ileal epithelium; ; lacrimal gland; ; parotid gland; ; seminal vesicula; ; calvaria; ; crypt of lieberkuhn of small intestine; ; secondary oocyte; ; molar; ; islet of Langerhans; ; stroma of bone marrow;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	Golgi membrane; membrane; Golgi apparatus; endoplasmic reticulum; endoplasmic reticulum membrane;
Biological process	organelle organization; Golgi organization; organelle assembly; spermatogenesis; cell differentiation; response to endoplasmic reticulum stress; establishment of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	26003
	70231
	ENSG00000115806
	ENSMUSG00000014959
	Q9H8Y8
	Q99JX3
	NM_001201428; NM_015530
	NM_027352
	NP_001188357; NP_056345
	NP_081628
	Wikidata
View/Edit Human	View/Edit Mouse

Golgi reassembly-stacking protein 2 ( GRS2) also known as Golgi reassembly-stacking protein of 55 kDa (GRASP55) is a protein that in humans is encoded by the GORASP2 gene. It was identified by its homology with GORASP1 and the protein's amino acid sequence was determined by analysis of a molecular clone of its complementary DNA. The first (N-terminus) 212 amino acid residues of GORASP2 are highly homologous to those of GORASP1, but the remainder of the 454 amino acid residues are highly diverged from GORASP1. The conserved region is known as the GRASP domain, and it is conserved among GRASPs of a wide variety of eukaryotes, but not plants. The C-terminus portion of the molecule is called the SPR domain (serine, proline-rich). GORASP2 is more closely related to homologues in other species, suggesting that GORASP2 is ancestral to GORASP1. GORASP2 is found associated with the medial and trans cisternae of the Golgi apparatus.