Platelet glycoprotein VI

GP6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GI7
Identifiers
Aliases	GP6, BDPLT11, GPIV, GPVI, glycoprotein VI platelet
External IDs	OMIM: 605546; MGI: 1889810; HomoloGene: 9488; GeneCards: GP6; OMA:GP6 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,038,264 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	4,400,743 bp
RNA expression pattern
	Top expressed in
	monocyte; ; testicle; ; gonad; ; blood; ; granulocyte; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; bone marrow cells; ; primary visual cortex; ; skin of abdomen;
	Top expressed in
	blood; ; bone marrow; ; spleen; ; zygote; ; yolk sac; ; genital tubercle; ; liver; ; heart; ; skeleton; ; leg;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; transmembrane signaling receptor activity; collagen binding; signaling receptor activity;
Cellular component	integral component of membrane; cell surface; plasma membrane; tetraspanin-enriched microdomain; extracellular exosome; membrane; integral component of plasma membrane;
Biological process	platelet activation; hemostasis; blood coagulation; enzyme linked receptor protein signaling pathway; leukocyte migration;
	Sources:Amigo / QuickGO
Orthologs
	51206
	243816
ENSG00000088053; ENSG00000274050; ENSG00000278670; ENSG00000276211; ENSG00000277439;
	ENSG00000278316; ENSG00000275633; ENSG00000274566; ENSG00000275931; ENSG00000276065
	ENSMUSG00000078810
	Q9HCN6
	P0C191
	NM_016363; NM_001083899; NM_001256017
	NM_001163014
	NP_001077368; NP_001242946; NP_057447
	NP_001156486
	Wikidata
View/Edit Human	View/Edit Mouse

Platelet glycoprotein VI (GPVI) is a glycoprotein receptor for collagen which is expressed in platelets. In humans, glycoprotein VI is encoded by the GP6 gene. It was first cloned in 2000 by several groups including that of Martine Jandrot-Perrus from INSERM.