Glypican 2

GPC2
Identifiers
Aliases	GPC2, Glypican 2
External IDs	OMIM: 618446; MGI: 1919201; HomoloGene: 17657; GeneCards: GPC2; OMA:GPC2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,177,381 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	138,278,267 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; skin of arm; ; ventricular zone; ; sperm; ; tendon of biceps brachii; ; pericardium; ; thymus; ; buccal mucosa cell; ; testicle; ; left testis;
	Top expressed in
	ganglionic eminence; ; Mesencephalon; ; ventricular zone; ; neural tube; ; genital tubercle; ; spermatocyte; ; granulocyte; ; lens; ; epiblast; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	heparan sulfate proteoglycan binding; protein binding;
Cellular component	membrane; plasma membrane; extracellular region; lysosomal lumen; endoplasmic reticulum; Golgi lumen; anchored component of membrane; extracellular space; anchored component of plasma membrane; collagen-containing extracellular matrix; cell surface; synapse;
Biological process	retinoid metabolic process; glycosaminoglycan catabolic process; glycosaminoglycan biosynthetic process; neuron differentiation; smoothened signaling pathway; regulation of signal transduction; positive regulation of neuron projection development; cell migration; regulation of protein localization to membrane;
	Sources:Amigo / QuickGO
Orthologs
	221914
	71951
	ENSG00000213420
	ENSMUSG00000029510
	Q8N158
	Q8BKV1
	NM_152742
	NM_172412
	NP_689955
	NP_766000
	Wikidata
View/Edit Human	View/Edit Mouse

Glypican 2 (GPC2), also known cerebroglycan, is a protein which in humans is encoded by the GPC2 gene. The GPC2 gene is at locus 7q22.1 and encodes for a 579 amino acid protein. The C-terminus of GPC2 has the GPI attachment site, at G554, and the N-terminus encodes a signal peptide, from M1 to S24. Multiple GPC2 mRNA transcripts have been identified. GPC2-201 is the isoform overexpressed in pediatric cancers. Tumor-associated exon 3 of GPC2 shows the lowest expression in normal tissues compared with other exons.