Glypican 3

GPC3
Identifiers
Aliases	GPC3, DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1, Glypican 3
External IDs	OMIM: 300037; MGI: 104903; HomoloGene: 20944; GeneCards: GPC3; OMA:GPC3 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	133,987,100 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	51,702,827 bp
RNA expression pattern
	Top expressed in
	upper lobe of left lung; ; right lung; ; tibial nerve; ; placenta; ; subcutaneous adipose tissue; ; anterior pituitary; ; cartilage tissue; ; right coronary artery; ; lower lobe of lung; ; left coronary artery;
	Top expressed in
	umbilical cord; ; abdominal wall; ; mandibular prominence; ; tail of embryo; ; genital tubercle; ; maxillary prominence; ; yolk sac; ; efferent ductule; ; Gonadal ridge; ; hand;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; protein binding; peptidyl-dipeptidase inhibitor activity; heparan sulfate proteoglycan binding;
Cellular component	membrane; anchored component of plasma membrane; plasma membrane; integral component of plasma membrane; extracellular region; lysosomal lumen; Golgi lumen; anchored component of membrane; lysosome; extracellular space; endoplasmic reticulum lumen; intrinsic component of plasma membrane; collagen-containing extracellular matrix;
Biological process	body morphogenesis; positive regulation of glucose import; bone mineralization; negative regulation of peptidase activity; negative regulation of growth; negative regulation of smoothened signaling pathway; positive regulation of protein catabolic process; positive regulation of smoothened signaling pathway; cell proliferation involved in metanephros development; lung development; kidney development; osteoclast differentiation; anatomical structure morphogenesis; mesenchymal cell proliferation involved in ureteric bud development; mesonephric duct morphogenesis; coronary vasculature development; retinoid metabolic process; cell proliferation involved in kidney development; positive regulation of endocytosis; branching involved in ureteric bud morphogenesis; glycosaminoglycan catabolic process; glycosaminoglycan biosynthetic process; negative regulation of epithelial cell proliferation; positive regulation of BMP signaling pathway; animal organ morphogenesis; regulation of growth; positive regulation of Wnt signaling pathway, planar cell polarity pathway; anterior/posterior axis specification; negative regulation of canonical Wnt signaling pathway; negative regulation of cell population proliferation; embryonic hindlimb morphogenesis; post-translational protein modification; regulation of signal transduction; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	2719
	14734
	ENSG00000147257
	ENSMUSG00000055653
	P51654
	Q8CFZ4
	NM_004484; NM_001164617; NM_001164618; NM_001164619
	NM_016697
	NP_001158089; NP_001158090; NP_001158091; NP_004475; NP_004475.1
	NP_057906
	Wikidata
View/Edit Human	View/Edit Mouse

Glypican-3 is a protein that, in humans, is encoded by the GPC3 gene. The GPC3 gene is located on human X chromosome (Xq26) where the most common gene (Isoform 2, GenBank Accession No.: NP_004475) encodes a 70-kDa core protein with 580 amino acids. Three variants have been detected that encode alternatively spliced forms termed Isoforms 1 (NP_001158089), Isoform 3 (NP_001158090) and Isoform 4 (NP_001158091).