Glypican 4

GPC4
Identifiers
Aliases	GPC4, K-glypican, glypican 4, KPTS
External IDs	OMIM: 300168; MGI: 104902; HomoloGene: 55582; GeneCards: GPC4; OMA:GPC4 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	133,415,489 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	51,254,129 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; gastric mucosa; ; right lung; ; thoracic aorta; ; ascending aorta; ; popliteal artery; ; tibial arteries; ; Descending thoracic aorta; ; muscle layer of sigmoid colon;
	Top expressed in
	stroma of bone marrow; ; cumulus cell; ; ascending aorta; ; human kidney; ; right kidney; ; calvaria; ; aortic valve; ; molar; ; ciliary body; ; ventricular zone;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	heparan sulfate proteoglycan binding; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway;
Cellular component	membrane; plasma membrane; integral component of plasma membrane; extracellular region; lysosomal lumen; Golgi lumen; anchored component of membrane; extracellular exosome; external side of plasma membrane; nucleus; extracellular space; synapse; anchored component of plasma membrane; collagen-containing extracellular matrix; glutamatergic synapse; anchored component of presynaptic membrane; cell surface;
Biological process	glycosaminoglycan metabolic process; anatomical structure morphogenesis; retinoid metabolic process; glycosaminoglycan catabolic process; glycosaminoglycan biosynthetic process; cell population proliferation; Wnt signaling pathway, planar cell polarity pathway; regulation of signal transduction; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; synaptic membrane adhesion; regulation of presynapse assembly; cell migration; regulation of protein localization to membrane;
	Sources:Amigo / QuickGO
Orthologs
	2239
	14735
	ENSG00000076716
	ENSMUSG00000031119
	O75487
	P51655
	NM_001448
	NM_008150
	NP_001439
	NP_032176
	Wikidata
View/Edit Human	View/Edit Mouse

Glypican-4 is a protein that in humans is encoded by the GPC4 gene.

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.