Glypican 5

GPC5
Identifiers
Aliases	GPC5, glypican 5
External IDs	OMIM: 602446; MGI: 1194894; HomoloGene: 3285; GeneCards: GPC5; OMA:GPC5 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	92,873,682 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	116,762,591 bp
RNA expression pattern
	Top expressed in
	testicle; ; caudate nucleus; ; putamen; ; endothelial cell; ; nucleus accumbens; ; entorhinal cortex; ; Pons; ; superior vestibular nucleus; ; Amygdala; ; external globus pallidus;
	Top expressed in
	substantia nigra; ; globus pallidus; ; deep cerebellar nuclei; ; dorsal tegmental nucleus; ; otolith organ; ; utricle; ; paraventricular nucleus of hypothalamus; ; lateral hypothalamus; ; inferior colliculi; ; medial vestibular nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparan sulfate proteoglycan binding;
Cellular component	integral component of plasma membrane; extracellular region; membrane; anchored component of membrane; Golgi lumen; plasma membrane; lysosomal lumen; extracellular space; anchored component of plasma membrane; integral component of membrane; collagen-containing extracellular matrix; cell surface;
Biological process	glycosaminoglycan biosynthetic process; retinoid metabolic process; glycosaminoglycan catabolic process; regulation of signal transduction; cell migration; positive regulation of canonical Wnt signaling pathway; regulation of protein localization to membrane;
	Sources:Amigo / QuickGO
Orthologs
	2262
	103978
	ENSG00000179399
	ENSMUSG00000022112
	P78333
	Q8CAL5
	NM_004466
	NM_175500
	NP_004457
	NP_780709
	Wikidata
View/Edit Human	View/Edit Mouse

Glypican-5 is a protein that in humans is encoded by the GPC5 gene.

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.