Glypican 6

GPC6
Identifiers
Aliases	GPC6, OMIMD1, Glypican 6
External IDs	OMIM: 604404; MGI: 1346322; HomoloGene: 55922; GeneCards: GPC6; OMA:GPC6 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	94,408,020 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	118,213,956 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; tibia; ; vena cava; ; superficial temporal artery; ; saphenous vein; ; seminal vesicula; ; pancreatic epithelial cell; ; spinal ganglia; ; synovial membrane; ; caput epididymis;
	Top expressed in
	ascending aorta; ; aortic valve; ; external carotid artery; ; internal carotid artery; ; sciatic nerve; ; genital tubercle; ; maxillary prominence; ; mandibular prominence; ; tail of embryo; ; human fetus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	heparan sulfate proteoglycan binding; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway; protein binding;
Cellular component	Golgi lumen; nucleus; integral component of plasma membrane; extracellular region; anchored component of membrane; lysosomal lumen; membrane; plasma membrane; extracellular space; anchored component of plasma membrane; collagen-containing extracellular matrix; glutamatergic synapse; cell surface; synapse;
Biological process	glycosaminoglycan metabolic process; retinoid metabolic process; cell migration; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; Wnt signaling pathway, planar cell polarity pathway; regulation of signal transduction; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of protein localization to membrane;
	Sources:Amigo / QuickGO
Orthologs
	10082
	23888
	ENSG00000183098
	ENSMUSG00000058571
	Q9Y625
	Q9R087
	NM_005708
	NM_001079844; NM_011821
	NP_005699
	NP_001073313; NP_035951
	Wikidata
View/Edit Human	View/Edit Mouse

Glypican-6 is a protein that in humans is encoded by the GPC6 gene.

The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans. The glypicans have been implicated in the control of cell growth and division. Glypican 6 is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases.