GPR143

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Ocular albinism type 1 protein
Ocular albinism type 1 protein
Identifiers
Symbol	Ocular_alb
Pfam	PF02101
Pfam clan	CL0192
InterPro	IPR001414
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

GPR143
Identifiers
Aliases	GPR143, NYS6, OA1, G protein-coupled receptor 143
External IDs	OMIM: 300808; MGI: 107193; HomoloGene: 230; GeneCards: GPR143; OMA:GPR143 - orthologs
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	151,591,642 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; retinal pigment epithelium; ; caudate nucleus; ; nucleus accumbens; ; putamen; ; cingulate gyrus; ; Amygdala; ; skin of abdomen; ; Brodmann area 9;
	Top expressed in
	iris; ; retinal pigment epithelium; ; hair follicle; ; ciliary body; ; embryo; ; stria vascularis; ; embryo; ; morula; ; endothelial cell of lymphatic vessel; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	L-DOPA binding; G protein-coupled receptor activity; signal transducer activity; dopamine binding; tyrosine binding; protein binding; L-DOPA receptor activity;
Cellular component	cytoplasm; integral component of membrane; Golgi apparatus; membrane; melanosome; melanosome membrane; lysosomal membrane; apical plasma membrane; lysosome; plasma membrane;
Biological process	eye pigment biosynthetic process; regulation of melanosome transport; melanosome localization; melanosome organization; melanosome transport; regulation of calcium-mediated signaling; regulation of melanosome organization; calcium-mediated signaling using intracellular calcium source; phosphatidylinositol-mediated signaling; signal transduction; visual perception; neuropeptide signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4935
	18241
	n/a
	ENSMUSG00000025333
	P51810
	P70259
	NM_000273
	NM_010951
	NP_000264
	NP_035081
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor 143, also known as Ocular albinism type 1 (OA1) in humans, is a conserved integral membrane protein with seven transmembrane domains and similarities with G protein-coupled receptors (GPCRs) that is expressed in the eye and epidermal melanocytes. This protein encoded by the GPR143 gene, whose variants can lead to Ocular albinism type 1.

The GPR143 gene is regulated by the Microphthalmia-associated transcription factor.

L-DOPA is an endogenous ligand for OA1.