G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene. The receptor has been shown to bind cholesin/C17orf50, a gut-derived hormone that is secreted from the intestine in response to dietary cholesterol absorption. In response to cholesin binding, GPR146 signaling inhibit cholesterol synthesis. Consistent with this interaction, murine genetic disruption of GPR146 lowers serum cholesterol and reduces atherosclerotic aortic lesions.
GPR146 has also been identified as a possible receptor for C-peptide.
