Protein wntless homolog

WLS
Identifiers
Aliases	WLS, C1orf139, EVI, GPR177, MRP, mig-14, wntless Wnt ligand secretion mediator, Wnt ligand secretion mediator, ZKS
External IDs	OMIM: 611514; MGI: 1915401; HomoloGene: 11779; GeneCards: WLS; OMA:WLS - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	68,233,120 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	159,644,300 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; Epithelium of choroid plexus; ; retinal pigment epithelium; ; corpus epididymis; ; gastric mucosa; ; islet of Langerhans; ; gallbladder; ; optic nerve; ; endothelial cell; ; bronchial epithelial cell;
	Top expressed in
	calvaria; ; molar; ; left lung lobe; ; olfactory epithelium; ; pineal gland; ; choroid plexus of fourth ventricle; ; maxillary prominence; ; right kidney; ; corneal stroma; ; seminal vesicula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; Wnt-protein binding; mu-type opioid receptor binding;
Cellular component	integral component of membrane; endocytic vesicle membrane; endosome; Golgi apparatus; early endosome membrane; membrane; plasma membrane; dendrite membrane; trans-Golgi network; early endosome; dendrite cytoplasm; extracellular exosome; cytoplasmic vesicle membrane; endoplasmic reticulum membrane; cytoplasmic vesicle; Golgi membrane; endoplasmic reticulum;
Biological process	exocrine pancreas development; positive regulation of canonical Wnt signaling pathway; positive regulation of Wnt protein secretion; mesoderm formation; hindbrain development; multicellular organism development; positive regulation of Wnt signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; intracellular protein transport; anterior/posterior axis specification; midbrain development; Wnt signaling pathway; Wnt protein secretion;
	Sources:Amigo / QuickGO
Orthologs
	79971
	68151
	ENSG00000116729
	ENSMUSG00000028173
	Q5T9L3
	Q6DID7
	NM_001002292; NM_001193334; NM_024911
	NM_026582; NM_001356349; NM_001356350
	NP_001002292; NP_001180263; NP_079187
	NP_080858; NP_001343278; NP_001343279
	Wikidata
View/Edit Human	View/Edit Mouse

Protein wntless homolog, commonly known as Wntless, is encoded in humans by the WLS gene. Wntless is a receptor for Wnt proteins in Wnt-secreting cells.

Wntless was shown to be a cargo for the retromer complex. It has been found essential for hair follicle induction.

A homozygous missense mutation in the WLS gene was identified in Zaki syndrome.