GPR183

GPR183
Identifiers
Aliases	GPR183, EBI2, G protein-coupled receptor 183, hEBI2
External IDs	OMIM: 605741; MGI: 2442034; HomoloGene: 28066; GeneCards: GPR183; OMA:GPR183 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	99,307,399 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	122,202,607 bp
RNA expression pattern
	Top expressed in
	appendix; ; gallbladder; ; lymph node; ; gonad; ; epithelium of nasopharynx; ; blood; ; granulocyte; ; spleen; ; rectum; ; superficial temporal artery;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; blood; ; thymus; ; bone marrow; ; subcutaneous adipose tissue; ; stroma of bone marrow; ; morula; ; ankle; ; dermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; oxysterol binding; G protein-coupled receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; B cell activation involved in immune response; mature B cell differentiation involved in immune response; humoral immune response; positive regulation of B cell proliferation; immune response; signal transduction; positive regulation of ERK1 and ERK2 cascade; immune system process; regulation of astrocyte chemotaxis; leukocyte chemotaxis; adaptive immune response; dendritic cell chemotaxis; T cell chemotaxis; osteoclast differentiation; dendritic cell homeostasis; cell chemotaxis; T follicular helper cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	1880
	321019
	ENSG00000169508
	ENSMUSG00000051212
	P32249
	Q3U6B2
	NM_004951
	NM_183031
	NP_004942
	NP_898852
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor 183 also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a protein (GPCR) expressed on the surface of some immune cells, namely B cells and T cells; in humans it is encoded by the GPR183 gene. Expression of EBI2 is one critical mediator of immune cell localization within lymph nodes, responsible in part for the coordination of B cell, T cell, and dendritic cell movement and interaction following antigen exposure. EBI2 is a receptor for oxysterols. The most potent activator is 7α,25-dihydroxycholesterol (7α,25-OHC), with other oxysterols exhibiting varying affinities for the receptor. Oxysterol gradients drive chemotaxis, attracting the EBI2-expressing cells to locations of high ligand concentration. The GPR183 gene was identified due to its upregulation during Epstein-Barr virus infection of the Burkitt's lymphoma cell line BL41, hence its name: EBI2.