GPR3

GPR3
Identifiers
Aliases	GPR3, ACCA, G protein-coupled receptor 3
External IDs	OMIM: 600241; MGI: 101908; HomoloGene: 31303; GeneCards: GPR3; OMA:GPR3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	27,395,814 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	132,939,847 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; testicle; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; right frontal lobe; ; right hemisphere of cerebellum; ; islet of Langerhans; ; primary visual cortex; ; right auricle of heart;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; facial motor nucleus; ; superior frontal gyrus; ; primary visual cortex; ; embryo; ; morula; ; morula; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; protein binding; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; intracellular anatomical structure;
Biological process	G protein-coupled receptor signaling pathway; regulation of meiotic nuclear division; adenylate cyclase-activating G protein-coupled receptor signaling pathway; signal transduction; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	2827
	14748
	ENSG00000181773
	ENSMUSG00000049649
	P46089
	P35413
	NM_005281
	NM_008154
	NP_005272
	NP_032180
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene. The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.

GPR3 mRNA is broadly expressed in neurons in various brain regions, including the cortex, thalamus, hypothalamus, amygdala, hippocampus, pituitary, and cerebellum. GPR3 mRNA is also expressed in the eye, lung, kidney, liver, testes, and ovary, among other tissues.

Individuals afflicted by Alzheimer's disease have in many cases, overexpression of the GPR3 protein in their neurons.