GPR98

ADGRV1
Identifiers
Aliases	ADGRV1, FEB4, MASS1, USH2B, USH2C, VLGR1, VLGR1b, GPR98, adhesion G protein-coupled receptor V1
External IDs	OMIM: 602851; MGI: 1274784; HomoloGene: 19815; GeneCards: ADGRV1; OMA:ADGRV1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	91,164,437 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	81,781,273 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal gland; ; ventricular zone; ; left adrenal cortex; ; ganglionic eminence; ; caudate nucleus; ; nucleus accumbens; ; putamen; ; Amygdala; ; anterior pituitary;
	Top expressed in
	neural layer of retina; ; ventricular zone; ; lens; ; spermatid; ; barrel cortex; ; cumulus cell; ; spermatocyte; ; optic nerve; ; embryo; ; saccule;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; G protein-coupled receptor activity; signal transducer activity; protein binding; transmembrane signaling receptor activity; G-protein alpha-subunit binding; adenylate cyclase inhibitor activity; hydrolase activity;
Cellular component	cytoplasm; integral component of membrane; membrane; receptor complex; plasma membrane; synapse; stereocilium; cell surface; extracellular exosome; photoreceptor inner segment; stereocilia ankle link; stereocilia ankle link complex; cell projection; stereocilium membrane; periciliary membrane compartment; USH2 complex;
Biological process	G protein-coupled receptor signaling pathway; response to stimulus; nervous system process; sensory perception of light stimulus; hearing; nervous system development; cell communication; cell surface receptor signaling pathway; photoreceptor cell maintenance; maintenance of animal organ identity; signal transduction; visual perception; cell-cell adhesion; negative regulation of adenylate cyclase activity; positive regulation of protein kinase A signaling; positive regulation of bone mineralization; regulation of protein stability; establishment of protein localization; inner ear development; detection of mechanical stimulus involved in sensory perception of sound; inner ear receptor cell stereocilium organization; cellular response to calcium ion; positive regulation of protein kinase C signaling; self proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	84059
	110789
	ENSG00000164199
	ENSMUSG00000069170
	Q8WXG9
	Q8VHN7
	NM_032119
	NM_054053
	NP_115495
	NP_473394
	Wikidata
View/Edit Human	View/Edit Mouse

ADGRV1, also known as G protein-coupled receptor 98 (GPR98) or Very Large G-protein coupled receptor 1 (VLGR1), is a protein that in humans is encoded by the GPR98 gene. Several alternatively spliced transcripts have been described.

The adhesion GPCR VLGR1 is the largest GPCR known, with a size of 6300 amino acids and consisting of 90 exons. There are 8 splice variants of VlgR1, named VlgR1a-1e and Mass1.1-1.3. The N-terminus consists of 5800 amino acids containing 35 Calx-beta domains, one pentraxin domain, and one epilepsy associated repeat. Mutations of VlgR1 have been shown to result in Usher's syndrome. Knockouts of Vlgr1 in mice have been shown to phenocopy Usher's syndrome and lead to audiogenic seizures.