GPRC5D

GPRC5D
Identifiers
Aliases	GPRC5D, G protein-coupled receptor, class C, group 5, member D, G protein-coupled receptor class C group 5 member D
External IDs	OMIM: 607437; MGI: 1935037; HomoloGene: 10250; GeneCards: GPRC5D; OMA:GPRC5D - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	12,952,170 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	135,095,281 bp
RNA expression pattern
	Top expressed in
	testicle; ; upper lobe of left lung; ; hair follicle; ; mucosa of transverse colon; ; rectum; ; right lung; ; minor salivary glands; ; bone marrow cells; ; mucosa of esophagus; ; islet of Langerhans;
	Top expressed in
	lip; ; blastocyst; ; embryo; ; hair follicle; ; skin of abdomen; ; embryo; ; skin of back; ; dermis; ; skin of external ear; ; sexually immature organism;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; protein kinase activator activity;
Cellular component	integral component of membrane; plasma membrane; membrane; receptor complex; intracellular membrane-bounded organelle; extracellular exosome;
Biological process	G protein-coupled receptor signaling pathway; signal transduction; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	55507
	93746
	ENSG00000111291
	ENSMUSG00000030205
	Q9NZD1
	Q9JIL6
	NM_018654
	NM_001205396; NM_053118
	NP_061124
	NP_001192325; NP_444348
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor family C group 5 member D is a protein that in humans is encoded by the GPRC5D gene. GPRC5D is a class C orphan G protein-coupled receptor predominantly expressed in multiple myeloma cells and hard keratinized tissues, with low expression in normal human tissues, rendering it an appealing target for multiple myeloma cells.