GPS1

GPS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D10, 4D18, 4WSN
Identifiers
Aliases	GPS1, COPS1, CSN1, SGN1, G protein pathway suppressor 1
External IDs	OMIM: 601934; MGI: 2384801; HomoloGene: 3046; GeneCards: GPS1; OMA:GPS1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	82,057,470 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,679,928 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; right hemisphere of cerebellum; ; gastrocnemius muscle; ; right frontal lobe; ; anterior pituitary; ; right testis; ; left testis; ; ganglionic eminence; ; right lobe of liver;
	Top expressed in
	spermatocyte; ; lens; ; Mesencephalon; ; neural tube; ; rhombencephalon; ; adrenal gland; ; dentate gyrus of hippocampal formation granule cell; ; olfactory bulb; ; ventricular zone; ; striatum of neuraxis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase inhibitor activity; protein binding;
Cellular component	cytoplasm; COP9 signalosome; nucleus; nucleoplasm; cytosol;
Biological process	JNK cascade; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA damage recognition; negative regulation of GTPase activity; protein deneddylation; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	2873
	209318
	ENSG00000169727
	ENSMUSG00000025156
	Q13098
	Q99LD4
NM_004127; NM_212492; NM_001321089; NM_001321090; NM_001321091;
	NM_001321092; NM_001321093; NM_001330539; NM_001330541
	NM_001177874; NM_145370; NM_001346709; NM_001363440
NP_001308018; NP_001308019; NP_001308020; NP_001308021; NP_001308022;
	NP_001317468; NP_001317470; NP_004118; NP_997657
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

The COP9 signalosome complex subunit 1 is a protein encoded by the GPS1 gene.

This gene is known to inhibit G-protein and mitogen-activated signal transduction in mammalian cells. The protein encoded by this gene shares significant similarity with Arabidopsis FUS6, a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.