GPS2 (gene)

GPS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L5G
Identifiers
Aliases	GPS2, AMF-1, G protein pathway suppressor 2
External IDs	OMIM: 601935; MGI: 1891751; HomoloGene: 49599; GeneCards: GPS2; OMA:GPS2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,315,564 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,807,417 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; sural nerve; ; muscle of thigh; ; gastrocnemius muscle; ; pituitary gland; ; anterior pituitary; ; granulocyte; ; apex of heart; ; right lobe of thyroid gland;
	Top expressed in
	neural layer of retina; ; granulocyte; ; muscle of thigh; ; tail of embryo; ; genital tubercle; ; lip; ; seminiferous tubule; ; yolk sac; ; ventricular zone; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase inhibitor activity; protein binding; cyclin binding; transcription coactivator activity; transcription corepressor activity;
Cellular component	nucleoplasm; nucleus; cytoplasm; mitochondrion; transcription repressor complex; cytosol;
Biological process	JNK cascade; negative regulation of GTPase activity; negative regulation of fat cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of cholesterol efflux; regulation of lipid metabolic process; B cell differentiation; negative regulation of toll-like receptor signaling pathway; positive regulation of peroxisome proliferator activated receptor signaling pathway; regulation of fat cell differentiation; positive regulation of transcription by RNA polymerase II; negative regulation of JNK cascade; negative regulation of inflammatory response; negative regulation of B cell receptor signaling pathway; response to mitochondrial depolarisation; negative regulation of protein K63-linked ubiquitination; transcription, DNA-templated; regulation of transcription, DNA-templated; viral process;
	Sources:Amigo / QuickGO
Orthologs
	2874
	56310
	ENSG00000132522
	ENSMUSG00000023170
	Q13227
	Q921N8
	NM_004489
	NM_019726; NM_001357906
	NP_004480
	NP_001344835; NP_062700
	Wikidata
View/Edit Human	View/Edit Mouse

G protein pathway suppressor 2 is a protein that in humans is encoded by the GPS2 gene.