GPSM1

GPSM1
Identifiers
Aliases	GPSM1, AGS3, G-protein signaling modulator 1, G protein signaling modulator 1
External IDs	OMIM: 609491; MGI: 1915089; HomoloGene: 16987; GeneCards: GPSM1; OMA:GPSM1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	136,359,605 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	26,238,249 bp
RNA expression pattern
	Top expressed in
	tibia; ; cardiac muscle tissue of right atrium; ; right hemisphere of cerebellum; ; retinal pigment epithelium; ; apex of heart; ; myocardium of left ventricle; ; ganglionic eminence; ; cerebellar vermis; ; sural nerve; ; right auricle of heart;
	Top expressed in
	Rostral migratory stream; ; neural layer of retina; ; saccule; ; barrel cortex; ; cerebellar cortex; ; olfactory bulb; ; atrioventricular valve; ; fossa; ; otic placode; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; GTPase regulator activity; GDP-dissociation inhibitor activity;
Cellular component	cytoplasm; cytosol; Golgi apparatus; endoplasmic reticulum; membrane; Golgi membrane; endoplasmic reticulum membrane; plasma membrane; cell cortex; protein-containing complex;
Biological process	multicellular organism development; cell differentiation; nervous system development; positive regulation of macroautophagy; negative regulation of GTPase activity; negative regulation of guanyl-nucleotide exchange factor activity;
	Sources:Amigo / QuickGO
Orthologs
	26086
	67839
	ENSG00000160360
	ENSMUSG00000026930
	Q86YR5
	Q6IR34
	NM_001145638; NM_001145639; NM_001200003; NM_015597
NM_001199146; NM_001199147; NM_153410; NM_001355574; NM_001355575;
	NM_001355576
	NP_001139110; NP_001139111; NP_001186932; NP_056412
NP_001186075; NP_001186076; NP_700459; NP_001342503; NP_001342504;
	NP_001342505
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein-signaling modulator 1 is a protein that in humans is encoded by the GPSM1 gene.

G proteins propagate intracellular signals initiated by G protein-coupled receptors. GPSM1, a receptor-independent activator of G protein signaling, is one of several factors that influence the basal activity of G protein signaling systems (Pizzinat et al., 2001).[supplied by OMIM]