Glutathione peroxidase 1

GPX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2F8A
Identifiers
Aliases	GPX1, GPXD, GSHPX1, glutathione peroxidase 1
External IDs	OMIM: 138320; MGI: 104887; HomoloGene: 20155; GeneCards: GPX1; OMA:GPX1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	49,358,353 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	108,217,542 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; right adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; gonad; ; right lung; ; spleen; ; subcutaneous adipose tissue;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; right kidney; ; left lobe of liver; ; blood; ; tibiofemoral joint; ; human fetus; ; cervix; ; granulocyte; ; submandibular gland; ; bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	peroxidase activity; SH3 domain binding; glutathione peroxidase activity; oxidoreductase activity;
Cellular component	cytoplasm; Lewy body; mitochondrial matrix; mitochondrion; cytosol;
Biological process	regulation of proteasomal protein catabolic process; intrinsic apoptotic signaling pathway in response to oxidative stress; myotube differentiation; response to selenium ion; positive regulation of protein kinase B signaling; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to drug; endothelial cell development; glutathione metabolic process; regulation of gene expression, epigenetic; blood vessel endothelial cell migration; lipid metabolism; negative regulation of release of cytochrome c from mitochondria; angiogenesis involved in wound healing; regulation of neuron apoptotic process; vasodilation; purine nucleotide catabolic process; negative regulation of apoptotic process; response to symbiotic bacterium; response to hydroperoxide; regulation of mammary gland epithelial cell proliferation; hearing; response to oxidative stress; cell redox homeostasis; lipoxygenase pathway; positive regulation of supramolecular fiber organization; myoblast proliferation; skeletal muscle tissue regeneration; negative regulation of inflammatory response to antigenic stimulus; response to wounding; skeletal muscle fiber development; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; biological process involved in interaction with symbiont; UV protection; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; temperature homeostasis; cell population proliferation; response to gamma radiation; triglyceride metabolic process; response to toxic substance; fat cell differentiation; apoptotic process; cellular oxidant detoxification; response to hydrogen peroxide; hydrogen peroxide catabolic process; heart contraction; response to reactive oxygen species; cellular response to oxidative stress;
	Sources:Amigo / QuickGO
Orthologs
	2876
	14775
	ENSG00000233276
	ENSMUSG00000063856
	P07203
	P11352
	NM_000581; NM_001329455; NM_001329502; NM_001329503; NM_201397
	NM_008160; NM_001329527; NM_001329528
	NP_000572; NP_001316384; NP_001316431; NP_001316432; NP_958799
	NP_001316456; NP_001316457; NP_032186
	Wikidata
View/Edit Human	View/Edit Mouse

Glutathione peroxidase 1, also known as GPx1, is an enzyme that in humans is encoded by the GPX1 gene on chromosome 3. This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans.