Glutathione peroxidase 3

GPX3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2R37
Identifiers
Aliases	GPX3, GPx-P, GSHPx-3, GSHPx-P, glutathione peroxidase 3
External IDs	OMIM: 138321; MGI: 105102; HomoloGene: 20480; GeneCards: GPX3; OMA:GPX3 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	151,028,988 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	54,801,203 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; right lung; ; left lobe of thyroid gland; ; gastric mucosa; ; lower lobe of lung; ; pericardium; ; upper lobe of left lung; ; human kidney; ; cardiac muscle tissue of right atrium; ; right auricle of heart;
	Top expressed in
	right kidney; ; gastrula; ; human kidney; ; decidua; ; vestibular membrane of cochlear duct; ; lactiferous gland; ; stroma of bone marrow; ; atrium; ; ankle; ; right lung;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; glutathione peroxidase activity; selenium binding; transcription factor binding; protein binding; peroxidase activity;
Cellular component	extracellular region; extracellular exosome; extracellular space;
Biological process	protein homotetramerization; response to oxidative stress; response to lipid hydroperoxide; hydrogen peroxide catabolic process; cellular oxidant detoxification; cellular response to oxidative stress;
	Sources:Amigo / QuickGO
Orthologs
	2878
	14778
	ENSG00000211445
	ENSMUSG00000018339
	P22352
	P46412
	NM_002084; NM_001329790
	NM_001083929; NM_008161; NM_001329860
	NP_001316719; NP_002075
	NP_001316789; NP_032187
	Wikidata
View/Edit Human	View/Edit Mouse

Glutathione peroxidase 3 (GPx-3), also known as plasma glutathione peroxidase (GPx-P) or extracellular glutathione peroxidase is an enzyme that in humans is encoded by the GPX3 gene.

GPx-3 belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.