Glutathione peroxidase 6

GPX6
Identifiers
Aliases	GPX6, GPX5p, GPXP3, GPx-6, GSHPx-6, dJ1186N24, dJ1186N24.1, glutathione peroxidase 6
External IDs	OMIM: 607913; MGI: 1922762; HomoloGene: 130008; GeneCards: GPX6; OMA:GPX6 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	28,528,215 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	21,503,794 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; olfactory zone of nasal mucosa; ; right testis; ; left testis; ; islet of Langerhans; ; lung; ; colon; ; wall of intestine; ; muscle layer of sigmoid colon;
	Top expressed in
	olfactory epithelium; ; spermatid; ; right kidney; ; zygote; ; outer renal medulla; ; seminiferous tubule; ; secondary oocyte; ; human kidney; ; primary oocyte; ; urethra;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; glutathione peroxidase activity; peroxidase activity;
Cellular component	extracellular region;
Biological process	cellular oxidant detoxification; response to oxidative stress;
	Sources:Amigo / QuickGO
Orthologs
	257202
	75512
	ENSG00000281185; ENSG00000198704
	ENSMUSG00000004341
	P59796
	Q91WR8
	NM_182701
	NM_145451
	NP_874360
	NP_663426
	Wikidata
View/Edit Human	View/Edit Mouse

Glutathione peroxidase 6 (GPx-6) is an enzyme that in humans is encoded by the GPX6 gene.

This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Expression of this gene is restricted to embryos and adult olfactory epithelium.