GRB10

GRB10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3HK0, 1NRV
Identifiers
Aliases	GRB10, GRB-IR, Grb-10, IRBP, MEG1, RSS, growth factor receptor bound protein 10
External IDs	OMIM: 601523; MGI: 103232; HomoloGene: 3882; GeneCards: GRB10; OMA:GRB10 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	50,793,462 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	11,988,683 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; pars compacta; ; visceral pleura; ; Brodmann area 23; ; pars reticulata; ; endothelial cell; ; dorsal motor nucleus of vagus nerve; ; middle temporal gyrus; ; pancreatic ductal cell; ; Epithelium of choroid plexus;
	Top expressed in
	mandibular prominence; ; endocardial cushion; ; atrium; ; maxillary prominence; ; atrioventricular valve; ; Gonadal ridge; ; abdominal wall; ; ureter; ; primitive streak; ; dermis;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; insulin receptor binding; identical protein binding;
Cellular component	cytoplasm; cytosol; plasma membrane; protein-containing complex;
Biological process	response to insulin; positive regulation of vascular endothelial growth factor receptor signaling pathway; negative regulation of glucose import; negative regulation of insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; negative regulation of phosphorylation; positive regulation of phosphorylation; negative regulation of glycogen biosynthetic process; signal transduction; insulin receptor signaling pathway; axon guidance; negative regulation of Wnt signaling pathway; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	2887
	14783
	ENSG00000106070
	ENSMUSG00000020176
	Q13322
	Q60760
NM_001001549; NM_001001550; NM_001001555; NM_005311; NM_001350814;
	NM_001350815; NM_001350816; NM_001371008; NM_001371009
	NM_001177629; NM_010345; NM_001370603
NP_001001549; NP_001001550; NP_001001555; NP_001337743; NP_001337744;
	NP_001337745; NP_001357937; NP_001357938
	NP_001171100; NP_034475; NP_001357532
	Wikidata
View/Edit Human	View/Edit Mouse

Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.