Gremlin (protein)
| gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | GREM1 | ||||||
| Alt. symbols | CKTSF1B1 | ||||||
| NCBI gene | 26585 | ||||||
| HGNC | 2001 | ||||||
| OMIM | 603054 | ||||||
| RefSeq | NM_013372 | ||||||
| UniProt | O60565 | ||||||
| Other data | |||||||
| Locus | Chr. 15 q11-13 | ||||||
| |||||||
| gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | GREM2 | ||||||
| NCBI gene | 64388 | ||||||
| HGNC | 17655 | ||||||
| OMIM | 608832 | ||||||
| RefSeq | NM_022469 | ||||||
| UniProt | Q9H772 | ||||||
| Other data | |||||||
| Locus | Chr. 1 q43 | ||||||
| |||||||
Gremlin is an inhibitor in the TGF beta signaling pathway. It primarily inhibits bone morphogenesis and is implicated in disorders of increased bone formation and several cancers.