GRIA2

GRIA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WJW, 2WJX, 2XHD, 3R7X, 3RN8, 3RNN, 3UA8, 5H8S
Identifiers
Aliases	GRIA2, GLUR2, GLURB, GluA2, GluR-K2, HBGR2, glutamate ionotropic receptor AMPA type subunit 2, gluR-B, gluR-2, NEDLIB
External IDs	OMIM: 138247; MGI: 95809; HomoloGene: 20225; GeneCards: GRIA2; OMA:GRIA2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	157,366,075 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	80,710,142 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; Brodmann area 23; ; middle temporal gyrus; ; Brodmann area 10; ; Region I of hippocampus proper; ; orbitofrontal cortex; ; parietal lobe; ; postcentral gyrus; ; cerebellar vermis; ; entorhinal cortex;
	Top expressed in
	lateral septal nucleus; ; CA3 field; ; anterior amygdaloid area; ; cingulate gyrus; ; subiculum; ; olfactory tubercle; ; entorhinal cortex; ; primary motor cortex; ; perirhinal cortex; ; ventromedial nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	ion channel activity; protein binding; ionotropic glutamate receptor activity; extracellularly glutamate-gated ion channel activity; excitatory extracellular ligand-gated ion channel activity; AMPA glutamate receptor activity; amyloid-beta binding; signaling receptor activity;
Cellular component	integral component of membrane; endocytic vesicle membrane; postsynaptic membrane; endoplasmic reticulum membrane; membrane; plasma membrane; synapse; integral component of plasma membrane; cell junction; endoplasmic reticulum; AMPA glutamate receptor complex; external side of plasma membrane; dendrite; dendritic spine; excitatory synapse; postsynapse; postsynaptic endocytic zone; postsynaptic density;
Biological process	ion transport; ion transmembrane transport; ionotropic glutamate receptor signaling pathway; transport; signal transduction; chemical synaptic transmission; excitatory postsynaptic potential; synaptic transmission, glutamatergic; regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	2891
	14800
	ENSG00000120251
	ENSMUSG00000033981
	P42262
	P23819
	NM_000826; NM_001083619; NM_001083620; NM_001379000; NM_001379001
	NM_001039195; NM_001083806; NM_013540; NM_001357924; NM_001357927
	NP_000817; NP_001077088; NP_001077089; NP_001365929; NP_001365930
	NP_001034284; NP_001077275; NP_038568; NP_001344853; NP_001344856
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate ionotropic receptor AMPA type subunit 2 (also known as glutamate receptor 2 or GluR-2) is a protein in humans that is encoded by the GRIA2 (also called GLUR2) gene. It functions as a subunit of AMPA receptors.