GRIA4

GRIA4
Identifiers
Aliases	GRIA4, GLUR4, GLUR4C, GLURD, GluA4, glutamate ionotropic receptor AMPA type subunit 4, NEDSGA, GluA4-ATD
External IDs	OMIM: 138246; MGI: 95811; HomoloGene: 20227; GeneCards: GRIA4; OMA:GRIA4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	105,982,092 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	4,796,234 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; prefrontal cortex; ; dorsolateral prefrontal cortex; ; anterior cingulate cortex; ; cerebellar vermis; ; right frontal lobe; ; Brodmann area 9; ; Pons; ; C1 segment;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; dorsal tegmental nucleus; ; anterior horn of spinal cord; ; deep cerebellar nuclei; ; dorsomedial hypothalamic nucleus; ; medial geniculate nucleus; ; ventral tegmental area; ; medial vestibular nucleus; ; lateral geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	ion channel activity; ionotropic glutamate receptor activity; extracellularly glutamate-gated ion channel activity; excitatory extracellular ligand-gated ion channel activity; AMPA glutamate receptor activity; protein binding; amyloid-beta binding; signaling receptor activity;
Cellular component	extracellular vesicle; integral component of membrane; endocytic vesicle membrane; postsynaptic membrane; cell projection; membrane; plasma membrane; synapse; cell junction; dendrite; AMPA glutamate receptor complex; soma; dendritic spine;
Biological process	glutamate receptor signaling pathway; ion transport; ion transmembrane transport; ionotropic glutamate receptor signaling pathway; excitatory postsynaptic potential; transport; regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	2893
	14802
	ENSG00000152578
	ENSMUSG00000025892
	P48058
	Q9Z2W8
	NM_000829; NM_001077243; NM_001077244; NM_001112812
	NM_001113180; NM_001113181; NM_019691
	NP_000820; NP_001070711; NP_001070712; NP_001106283
	NP_001106651; NP_001106652; NP_062665
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate receptor 4 is a protein that in humans is encoded by the GRIA4 gene.

This gene is a member of a family of L-glutamate-gated ion channels that mediate fast synaptic excitatory neurotransmission. These channels are also responsive to the glutamate agonist, alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionate (AMPA). Some haplotypes of this gene show a positive association with schizophrenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Like the other AMPA receptor subunits, GluA4 occurs as flip and flop spliced variant. In addition, GluA4 CTD long and short isoforms exist, and presumably an ATD-only isoform (433 aa).