GRID2

GRID2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5KCA, 5KC8
Identifiers
Aliases	GRID2, GluD2, SCAR18, glutamate ionotropic receptor delta type subunit 2
External IDs	OMIM: 602368; MGI: 95813; HomoloGene: 74399; GeneCards: GRID2; OMA:GRID2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	93,810,157 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	64,681,307 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; testicle; ; right hemisphere of cerebellum; ; gonad; ; ventricular zone; ; ganglionic eminence; ; corpus callosum; ; nucleus accumbens; ; prefrontal cortex;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; lumbar subsegment of spinal cord; ; motor neuron; ; vestibular membrane of cochlear duct; ; substantia nigra; ; facial motor nucleus; ; urethra; ; dorsomedial hypothalamic nucleus; ; deep cerebellar nuclei;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glutamate receptor activity; PDZ domain binding; scaffold protein binding; ion channel activity; ionotropic glutamate receptor activity; extracellularly glutamate-gated ion channel activity; protein binding; signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; postsynaptic membrane; membrane; plasma membrane; dendritic spine; synapse; integral component of plasma membrane; cell junction; ionotropic glutamate receptor complex; somatodendritic compartment; parallel fiber to Purkinje cell synapse; glutamatergic synapse; integral component of postsynaptic density membrane;
Biological process	glutamate receptor signaling pathway; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; regulation of neuron projection development; synaptic transmission, glutamatergic; regulation of neuron apoptotic process; ion transport; ion transmembrane transport; ionotropic glutamate receptor signaling pathway; excitatory postsynaptic potential; cerebellar granule cell differentiation; prepulse inhibition; positive regulation of synapse assembly; positive regulation of long-term synaptic depression; excitatory synapse assembly; regulation of postsynaptic density assembly; modulation of chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	2895
	14804
	ENSG00000152208
	ENSMUSG00000071424
	O43424
	Q61625
	NM_001286838; NM_001510
	NM_008167; NM_001370966
	NP_001273767; NP_001501
	NP_032193; NP_001357895
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate receptor, ionotropic, delta 2, also known as GluD2, GluRδ2, or δ₂, is a protein that in humans is encoded by the GRID2 gene. This protein together with GluD1 belongs to the delta receptor subtype of ionotropic glutamate receptors. They possess 14–24% sequence homology with AMPA, kainate, and NMDA subunits, but, despite their name, have been found not to directly promote neuronal activation in response to glutamate or various other glutamate agonists.

delta iGluRs have long been considered orphan receptors as their endogenous ligand was unknown. They are now believed to bind glycine and D-serine but these do not result in channel opening.