G protein-coupled receptor kinase 3

GRK3
Identifiers
Aliases	GRK3, BARK2, ADRBK2, Beta adrenergic receptor kinase-2, G protein-coupled receptor kinase 3
External IDs	OMIM: 109636; MGI: 87941; HomoloGene: 21072; GeneCards: GRK3; OMA:GRK3 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	25,729,294 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	113,163,657 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; endothelial cell; ; pars compacta; ; parietal pleura; ; monocyte; ; parietal lobe; ; postcentral gyrus; ; entorhinal cortex; ; sperm;
	Top expressed in
	Rostral migratory stream; ; subiculum; ; substantia nigra; ; submandibular gland; ; medial dorsal nucleus; ; anterior amygdaloid area; ; cerebellar vermis; ; medial geniculate nucleus; ; lobe of cerebellum; ; parotid gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor kinase activity; ATP binding; transferase activity; protein kinase activity; nucleotide binding; protein serine/threonine kinase activity; kinase activity; beta-adrenergic receptor kinase activity;
Cellular component	plasma membrane; cytosol;
Biological process	protein phosphorylation; receptor internalization; phosphorylation; signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	157
	320129
	ENSG00000100077
	ENSMUSG00000042249
	P35626
	Q3UYH7
	NM_005160; NM_001362778
	NM_001035531; NM_001285806; NM_177078
	NP_005151; NP_001349707
	NP_001272735; NP_796052
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein-coupled receptor kinase 3 (GRK3) is an enzyme that in humans is encoded by the ADRBK2 gene. GRK3 was initially called Beta-adrenergic receptor kinase 2 (βARK-2), and is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases that is most highly similar to GRK2.