Metabotropic glutamate receptor 2

GRM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4XAQ, 4XAS, 5CNI, 5CNJ
Identifiers
Aliases	GRM2, GPRC1B, MGLUR2, mGlu2, glutamate metabotropic receptor 2, mGluR2, GLUR2
External IDs	OMIM: 604099; MGI: 1351339; HomoloGene: 20229; GeneCards: GRM2; OMA:GRM2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	51,718,613 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	106,533,281 bp
RNA expression pattern
	Top expressed in
	vena cava; ; right frontal lobe; ; prefrontal cortex; ; right testis; ; left testis; ; Brodmann area 9; ; endothelial cell; ; ganglionic eminence; ; Pons; ; gonad;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; mammillary body; ; prefrontal cortex; ; olfactory bulb; ; hippocampus proper; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glutamate receptor activity; G protein-coupled receptor activity; group II metabotropic glutamate receptor activity; calcium channel regulator activity; signal transducer activity; protein binding;
Cellular component	integral component of membrane; cell projection; membrane; plasma membrane; synapse; integral component of plasma membrane; intracellular anatomical structure; axon; cell junction; dendrite; neuron projection; presynaptic membrane; integral component of postsynaptic membrane;
Biological process	negative regulation of adenylate cyclase activity; glutamate secretion; signal transduction; chemical synaptic transmission; regulation of synaptic transmission, glutamatergic; adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; G protein-coupled glutamate receptor signaling pathway; G protein-coupled receptor signaling pathway; glutamate homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	2912
	108068
	ENSG00000164082
	ENSMUSG00000023192
	Q14416
	Q14BI2
	NM_000839; NM_001349116; NM_001349117
	NM_001160353
	NP_000830; NP_001336045; NP_001336046
	NP_001153825
	Wikidata
View/Edit Human	View/Edit Mouse

Metabotropic glutamate receptor 2 (mGluR2) is a protein that, in humans, is encoded by the GRM2 gene. mGluR2 is a G protein-coupled receptor (GPCR) that couples with the Gi alpha subunit. The receptor functions as an autoreceptor for glutamate, that upon activation, inhibits the emptying of vesicular contents at the presynaptic terminal of glutamatergic neurons.