Metabotropic glutamate receptor 4

GRM4
Identifiers
Aliases	GRM4, GPRC1D, MGLUR4, mGlu4, glutamate metabotropic receptor 4
External IDs	OMIM: 604100; MGI: 1351341; HomoloGene: 20230; GeneCards: GRM4; OMA:GRM4 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	34,155,622 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	27,740,377 bp
RNA expression pattern
	Top expressed in
	paraflocculus of cerebellum; ; right hemisphere of cerebellum; ; cerebellar vermis; ; nucleus accumbens; ; putamen; ; caudate nucleus; ; Brodmann area 10; ; middle frontal gyrus; ; islet of Langerhans; ; quadriceps femoris muscle;
	Top expressed in
	cerebellar cortex; ; cerebellar vermis; ; lobe of cerebellum; ; zygote; ; secondary oocyte; ; medial dorsal nucleus; ; primary oocyte; ; medial geniculate nucleus; ; olfactory tubercle; ; nucleus of stria terminalis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glutamate receptor activity; G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; intracellular anatomical structure; presynaptic membrane; cytoplasmic vesicle; membrane;
Biological process	regulation of neuron apoptotic process; adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; neurotransmitter secretion; positive regulation of MAPK cascade; signal transduction; chemical synaptic transmission; regulation of synaptic transmission, glutamatergic; G protein-coupled receptor signaling pathway; G protein-coupled glutamate receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2914
	268934
	ENSG00000124493
	ENSMUSG00000063239
	Q14833
	Q68EF4
NM_000841; NM_001256809; NM_001256810; NM_001256811; NM_001256812;
	NM_001256813; NM_001256814; NM_001282847
	NM_001013385; NM_001291045; NM_001360192; NM_001379317
NP_000832; NP_001243738; NP_001243740; NP_001243741; NP_001243742;
	NP_001269776
	NP_001013403; NP_001277974; NP_001347121
	Wikidata
View/Edit Human	View/Edit Mouse

Metabotropic glutamate receptor 4 is a protein that in humans is encoded by the GRM4 gene.

Together with GRM6, GRM7 and GRM8 it belongs to group III of the metabotropic glutamate receptor family. Group III receptors are linked to the inhibition of the cyclic AMP cascade. Activation of GRM4 has potential therapeutic benefits in the treatment of parkinson's disease. Splice variant "taste-GRM4" is involved in the perception of umami taste.