GRWD1

GRWD1
Identifiers
Aliases	GRWD1, CDW4, GRWD, RRB1, WDR28, glutamate-rich WD repeat containing 1, glutamate rich WD repeat containing 1
External IDs	OMIM: 610597; MGI: 2141989; HomoloGene: 6644; GeneCards: GRWD1; OMA:GRWD1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,457,022 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,480,368 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; stromal cell of endometrium; ; olfactory bulb; ; gonad; ; muscle of thigh; ; mucosa of esophagus; ; left uterine tube; ; skin of leg; ; apex of heart; ; granulocyte;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; yolk sac; ; epiblast; ; condyle; ; primitive streak; ; fossa; ; somite; ; endothelial cell of lymphatic vessel; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	chromatin binding; DNA replication origin binding; RNA binding; protein binding; histone binding;
Cellular component	nucleus; nucleolus; cytosol; chromosome; protein-containing complex;
Biological process	nucleosome assembly; nucleosome disassembly; DNA replication;
	Sources:Amigo / QuickGO
Orthologs
	83743
	101612
	ENSG00000105447
	ENSMUSG00000053801
	Q9BQ67
	Q810D6
	NM_031485
	NM_153419
	NP_113673
	NP_700468
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate-rich WD repeat-containing protein 1 is a WD40 repeat protein (containing five WD40 repeat motifs) that in humans is encoded by the GRWD1 gene. It localizes to the nucleus and has known functions in regulating chromatin accessibility and loading of the MCM helicase. GRWD1 has also been shown to play a critical role in ribosome biogenesis.