GRXCR1

GRXCR1
Identifiers
Aliases	GRXCR1, DFNB25, PPP1R88, glutaredoxin and cysteine rich domain containing 1
External IDs	OMIM: 613283; MGI: 3577767; HomoloGene: 42423; GeneCards: GRXCR1; OMA:GRXCR1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	43,030,658 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	68,323,741 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; right frontal lobe; ; anterior cingulate cortex; ; prostate;
	Top expressed in
	endolymphatic duct; ; vestibular labyrinth; ; utricle; ; blastocyst; ; testicle; ; neural tube;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-disulfide reductase activity; electron transfer activity; molecular function;
Cellular component	cell projection; stereocilium; cilium; kinocilium; microvillus;
Biological process	inner ear receptor cell development; negative regulation of phosphatase activity; inner ear receptor cell stereocilium organization; hearing; vestibular receptor cell development; cell redox homeostasis; electron transport chain;
	Sources:Amigo / QuickGO
Orthologs
	389207
	433899
	ENSG00000215203
	ENSMUSG00000068082
	A8MXD5
	Q50H32
	NM_001080476
	NM_001018019
	NP_001073945
	NP_001018019
	Wikidata
View/Edit Human	View/Edit Mouse

Glutaredoxin domain-containing cysteine-rich protein 1 is a protein that in humans is encoded by the GRXCR1 gene.

This gene is one of 60 loci associated with autosomal-recessive nonsyndromic hearing impairment. This gene encodes a protein which contains GRX-like domains; these domains play a role in the S-glutathionylation of proteins and may be involved in actin organization in hair cells.