GSDMD

GSDMD
Identifiers
Aliases	GSDMD, DF5L, DFNA5L, GSDMDC1, FKSG10, gasdermin D
External IDs	OMIM: 617042; MGI: 1916396; HomoloGene: 12299; GeneCards: GSDMD; OMA:GSDMD - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	143,563,062 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	75,739,257 bp
RNA expression pattern
	Top expressed in
	spleen; ; mucosa of transverse colon; ; granulocyte; ; right lobe of liver; ; duodenum; ; blood; ; right lobe of thyroid gland; ; apex of heart; ; upper lobe of left lung; ; right lung;
	Top expressed in
	granulocyte; ; jejunum; ; duodenum; ; epithelium of small intestine; ; ileum; ; large intestine; ; colon; ; mesenteric lymph nodes; ; left colon; ; bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; phosphatidylserine binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidic acid binding; cardiolipin binding;
Cellular component	cytoplasm; inflammasome complex; nucleoplasm; NLRP3 inflammasome complex; extracellular region; extracellular space; cytosol; plasma membrane; membrane; specific granule lumen; tertiary granule lumen; ficolin-1-rich granule lumen;
Biological process	cellular response to extracellular stimulus; innate immune response; inflammatory response; programmed cell death; immune system process; pyroptosis; cytolysis; pore formation in membrane of other organism; neutrophil degranulation; pore complex assembly; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; protein homooligomerization;
	Sources:Amigo / QuickGO
Orthologs
	79792
	69146
	ENSG00000278718; ENSG00000104518
	ENSMUSG00000022575
	P57764
	Q9D8T2
	NM_001166237; NM_024736
	NM_026960
	NP_001159709; NP_079012
	NP_081236
	Wikidata
View/Edit Human	View/Edit Mouse

Gasdermin D (GSDMD, from combination of gastro and dermato, referencing the locations where its family of proteins were originally found to be primarily expressed) is a protein that in humans is encoded by the GSDMD gene on chromosome 8. It belongs to the gasdermin family which is conserved among vertebrates and comprises six members in humans, GSDMA, GSDMB, GSDMC, GSDMD, GSDME (DFNA5) and DFNB59 (Pejvakin). Members of the gasdermin family are expressed in a variety of cell types including epithelial cells and immune cells. GSDMA, GSDMB, GSDMC, GSDMD and GSDME have been suggested to act as tumour suppressors.