GSPT2

GSPT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3KUJ
Identifiers
Aliases	GSPT2, ERF3B, GST2, G1 to S phase transition 2
External IDs	OMIM: 300418; MGI: 1316727; HomoloGene: 99786; GeneCards: GSPT2; OMA:GSPT2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	51,746,232 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	93,686,850 bp
RNA expression pattern
	Top expressed in
	sperm; ; germinal epithelium; ; Epithelium of choroid plexus; ; ventricular zone; ; gonad; ; ganglionic eminence; ; Brodmann area 23; ; middle temporal gyrus; ; retinal pigment epithelium; ; hair follicle;
	Top expressed in
	seminal vesicula; ; primary oocyte; ; zygote; ; secondary oocyte; ; dorsomedial hypothalamic nucleus; ; suprachiasmatic nucleus; ; efferent ductule; ; ventromedial nucleus; ; subiculum; ; lateral septal nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; translation release factor activity; protein binding; GTPase activity; RNA binding;
Cellular component	cytoplasm; cytosol; translation release factor complex;
Biological process	translational termination; cell cycle; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; cytoplasmic translational termination; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
	23708
	14853
	ENSG00000189369
	ENSMUSG00000071723
	Q8IYD1
	Q149F3
	NM_018094
	NM_008179
	NP_060564
	NP_032205
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic peptide chain release factor GTP-binding subunit ERF3B is an enzyme that in humans is encoded by the GSPT2 gene.

GSPT2 is closely related to GSPT1 (MIM 139259), a GTP-binding protein that plays an essential role at the G1- to S-phase transition of the cell cycle in yeast and human cells. GSPT1 is a positive regulator of translational accuracy and, in a binary complex with eRF1 (MIM 600285), functions as a polypeptide chain release factor.[supplied by OMIM]