GSX1

GSX1
Identifiers
Aliases	GSX1, GSH1, Gsh-1, GS homeobox 1
External IDs	OMIM: 616542; MGI: 95842; HomoloGene: 17092; GeneCards: GSX1; OMA:GSX1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	27,794,768 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	147,127,757 bp
RNA expression pattern
	Top expressed in
	Hypothalamus; ; nucleus accumbens; ; hippocampal formation; ; temporal lobe; ; anterior cingulate cortex; ; hippocampus proper; ; prefrontal cortex; ; Amygdala; ; dorsolateral prefrontal cortex; ; Mesencephalon;
	Top expressed in
	glomerulus; ; urethra; ; embryo; ; female urethra; ; male urethra; ; hair; ; medial ganglionic eminence; ; embryo; ; pretectal area; ; optic stalk;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	multicellular organism development; neuron fate commitment; regulation of transcription, DNA-templated; transcription by RNA polymerase II; adenohypophysis development; spinal cord association neuron differentiation; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; hypothalamus development;
	Sources:Amigo / QuickGO
Orthologs
	219409
	14842
	ENSG00000169840
	ENSMUSG00000053129
	Q9H4S2
	P31315
	NM_145657
	NM_008178
	NP_663632
	NP_032204
	Wikidata
View/Edit Human	View/Edit Mouse

GS homeobox 1 (GSX1) is a protein encoded by the gene of the same name, located on chromosome 13 in humans and chromosome 5 in mice.

GSX1 is part of the homeobox gene family and acts as a transcription factor. It is essential for the expression of growth hormone-releasing hormone (GHRH) and is crucial for the development of neurons involved in sensory processing, particularly in prepulse inhibition.

Additionally, GSX1 is implicated in spinal cord injury recovery, promoting neural stem cell proliferation and enhancing locomotor function in injured mice.