GTPBP1

GTPBP1
Identifiers
Aliases	GTPBP1, GP-1, GP1, HSPC018, GTP binding protein 1
External IDs	OMIM: 602245; MGI: 109443; HomoloGene: 3165; GeneCards: GTPBP1; OMA:GTPBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	38,738,299 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	79,605,680 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; gastric mucosa; ; ventricular zone; ; ganglionic eminence; ; right uterine tube; ; left lobe of thyroid gland; ; skin of leg; ; popliteal artery; ; tibial arteries; ; left ovary;
	Top expressed in
	neural layer of retina; ; granulocyte; ; dentate gyrus of hippocampal formation granule cell; ; lip; ; ventricular zone; ; thymus; ; secondary oocyte; ; fetal liver hematopoietic progenitor cell; ; zygote; ; molar;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; RNA binding; GTPase activity; translation elongation factor activity;
Cellular component	cytoplasm; cytoplasmic exosome (RNase complex); cytosol; membrane;
Biological process	positive regulation of mRNA catabolic process; immune response; signal transduction; GTP metabolic process; translational elongation;
	Sources:Amigo / QuickGO
Orthologs
	9567
	14904
	ENSG00000100226
	ENSMUSG00000042535
	O00178
	O08582
	NM_004286
	NM_013818
	NP_004277
	NP_038846
	Wikidata
View/Edit Human	View/Edit Mouse

GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP1 gene.

This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mice, where disruption of the gene for that protein had no observable phenotype.