GTSE1

GTSE1
Identifiers
Aliases	GTSE1, B99, G2 and S-phase expressed 1
External IDs	OMIM: 607477; MGI: 1352755; HomoloGene: 8489; GeneCards: GTSE1; OMA:GTSE1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	46,330,810 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	85,760,774 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; buccal mucosa cell; ; pancreatic ductal cell; ; periodontal fiber; ; sperm; ; cardia; ; ventricular zone; ; endothelial cell; ; pylorus; ; nipple;
	Top expressed in
	zygote; ; tail of embryo; ; secondary oocyte; ; epiblast; ; yolk sac; ; ventricular zone; ; blastocyst; ; embryo; ; genital tubercle; ; primary oocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; molecular function;
Cellular component	cytoplasm; cytoplasmic microtubule; microtubule; cytoskeleton; membrane; cytosol; nucleoplasm;
Biological process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; microtubule-based process; regulation of cell cycle G2/M phase transition; negative regulation of microtubule binding; positive regulation of protein localization to nucleus; proteasome-mediated ubiquitin-dependent protein catabolic process; positive regulation of protein export from nucleus; protein stabilization; positive regulation of cell migration;
	Sources:Amigo / QuickGO
Orthologs
	51512
	29870
	ENSG00000075218
	ENSMUSG00000022385
	Q9NYZ3
	Q8R080
	NM_016426
	NM_001168672; NM_013882
	NP_057510
	NP_001162143; NP_038910
	Wikidata
View/Edit Human	View/Edit Mouse

G2 and S phase-expressed protein 1 is an enzyme that in humans is encoded by the GTSE1 gene.

The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.