Guanylate cyclase 2C

GUCY2C
Identifiers
Aliases	GUCY2C, DIAR6, GUC2C, MECIL, MUCIL, STAR, guanylate cyclase 2C, GC-C
External IDs	OMIM: 601330; MGI: 106903; HomoloGene: 3641; GeneCards: GUCY2C; OMA:GUCY2C - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	14,696,599 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	136,758,763 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of sigmoid colon; ; rectum; ; duodenum; ; mucosa of ileum; ; mucosa of transverse colon; ; testicle; ; secondary oocyte; ; epithelium of colon; ; appendix;
	Top expressed in
	jejunum; ; colon; ; duodenum; ; ileum; ; epithelium of small intestine; ; intestinal villus; ; Ileal epithelium; ; lymph node; ; crypt of lieberkuhn; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase activity; nucleotide binding; GTP binding; protein binding; lyase activity; phosphorus-oxygen lyase activity; ATP binding; toxic substance binding; guanylate cyclase activity; adenylate cyclase activity; peptide receptor activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; guanylate cyclase complex, soluble; plasma membrane;
Biological process	intracellular signal transduction; cyclic nucleotide biosynthetic process; receptor guanylyl cyclase signaling pathway; protein phosphorylation; regulation of cell population proliferation; response to toxic substance; cGMP biosynthetic process; digestion; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	2984
	14917
	ENSG00000070019
	ENSMUSG00000042638
	P25092
	Q3UWA6
	NM_004963
	NM_001127318; NM_145067
	NP_004954
	NP_001120790; NP_659504
	Wikidata
View/Edit Human	View/Edit Mouse

Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the GUCY2C gene.

Guanylyl cyclase is an enzyme found in the luminal aspect of intestinal epithelium and dopamine neurons in the brain. The receptor has an extracellular ligand-binding domain, a single transmembrane region, a region with sequence similar to that of protein kinases, and a C-terminal guanylate cyclase domain. Tyrosine kinase activity mediates the GC-C signaling pathway within the cell.