GUF1

GUF1
Identifiers
Aliases	GUF1, EF-4, GUF1 homolog, GTPase, EIEE40, EF4, GTP binding elongation factor DEE40
External IDs	OMIM: 617064; MGI: 2140726; HomoloGene: 6505; GeneCards: GUF1; OMA:GUF1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	44,700,928 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	69,733,316 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; gastrocnemius muscle; ; biceps brachii; ; muscle of thigh; ; ganglionic eminence; ; Skeletal muscle tissue of rectus abdominis; ; Achilles tendon; ; anterior cingulate cortex; ; rectum; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	tail of embryo; ; ventricular zone; ; hand; ; neural layer of retina; ; otolith organ; ; right kidney; ; muscle of thigh; ; utricle; ; lens; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; hydrolase activity; GTPase activity; ribosome binding;
Cellular component	mitochondrial inner membrane; membrane; mitochondrion; mitochondrial matrix;
Biological process	protein biosynthesis; positive regulation of translation;
	Sources:Amigo / QuickGO
Orthologs
	60558
	231279
	ENSG00000151806
	ENSMUSG00000029208
	Q8N442
	Q8C3X4
	NM_021927; NM_001345867; NM_001345868; NM_001345869
	NM_172711; NM_182768; NM_001310631
	NP_001332796; NP_001332797; NP_001332798; NP_068746
	NP_001297560; NP_766299
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial GTP binding elongation factor (Homo Sapiens, GUF1), is a protein which in humans is encoded by the GUF1 gene. The GUF1 protein plays an important role in maintaining proper mitochondrial function, ensuring accuracy when mitochondrial genes are being translated. The gene shows the most expression in the brain, while the least expression is found in the pancreas.