GZMM

GZMM
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2ZGC, 2ZGH, 2ZGJ, 2ZKS
Identifiers
Aliases	GZMM, LMET1, MET1, granzyme M
External IDs	OMIM: 600311; MGI: 99549; HomoloGene: 21099; GeneCards: GZMM; OMA:GZMM - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	549,924 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,531,095 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; spleen; ; lymph node; ; appendix; ; mucosa of transverse colon; ; thymus; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; bone marrow;
	Top expressed in
	neural layer of retina; ; muscle of thigh; ; morula; ; retinal pigment epithelium; ; interventricular septum; ; olfactory epithelium; ; embryo; ; embryo; ; granulocyte; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; endopeptidase activity; serine-type endopeptidase activity; hydrolase activity; protein binding;
Cellular component	extracellular region; membrane;
Biological process	innate immune response; cell death; cytolysis; proteolysis; immune system process; apoptotic process; T cell mediated cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
	3004
	16904
	ENSG00000197540
	ENSMUSG00000054206
	P51124
	n/a
	NM_005317; NM_001258351
	NM_008504; NM_001302485; NM_001302499
	NP_001245280; NP_005308
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Granzyme M is a protein that in humans is encoded by the GZMM gene.

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M.